Many of us have had questions about syncing the Pre with Macs. I sent this question to Sprint Public Relations and this is the answer they were kind enough to give me, so I hope it answers the questions of others:

"You can move files to a Mac via USB. Mac recognizes device as mass storage.

"I presume you are more interested in synching email, calendars, tasks, etc. There is no native support to synch with Mac OSX, but 3rd party apps that do this will be pervasive (like Mark/Space)."

"Hope this helps answer your questions."