Most of you may know this, but I have not found it in the forums since I got my Treo 650 in June of last year. If you have trouble getting the computer to recognize your cable and phone on the first hotsync...Unplug the charger from the hotsync cable. Your phone should already be charged fully, but the manual says to have the power cable plugged in. This is not necessary and hinders the computer from recognizing the phone. I had problems and have helped several others with the same problem.

My two cents...
Goat