AUPT-Compatibility
WebOS Quick Install is fully compatible with webOS-Internals Auto-Update Patch Technology (AUPT). Essentially this means you no longer need to uninstall patches prior to OTA updates.
When you enter the Tweaks section, after a webOS update, WebOS Quick Install will detect the version change and will open the update helper.
For on-feed patches, the update helper will update out-of-date patches to the new version's equivalent (or a dummy package if the updated patch has not yet been released).
For
.patch files installed with WebOS Quick Install, the update helper will uninstall them. It will also check to see if the patch can be successfully re-applied. If it can be re-applied, the patch will be reinstalled.
Tweaks Guide
The guide attached to this post is slightly out of date, but the majority of the tweaks are still listed and explained so it's still very useful for new users
Also, keep in mind, patches are shown in the Device Management section, just change the drop-down box from "Applications" to "Patches" and you'll be able to get info and be able to uninstall patches in bulk.
All tweaks are compatible and interoperable between WebOS Quick Install and Preware.