There are advantages and disadvantages to both. Cannot speak specifically about the Pre's screen, but from other past Palm devices...

Pro Plastic: Less likely to break.

Con Plastic: After heavy use a plastic digitizer may deform and start to have localized inaccuracies. (In my wife's and my personal experiences, after about 1 year.) Recalibration does not help and if bad enough can put the device into a recalibration loop. Now with the WebOS being finger centric and not stylus centric the Pre will probably not as sensitive to this issue.

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